The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …

The striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a
diverse array of cellular and synaptic functions that control goal-directed actions and habits …

Neural circuits are formed and refined during childhood, including via critical changes in
neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic excitability. We …

Optimizing cell substrates by surface modification of neural stem cells (NSCs), for efficient
and oriented neurogenesis, represents a promising strategy for treating neurological …

This review provides an overview of the synaptic dysfunctions of neuronal circuits and
underlying neurochemical alterations observed in the hyperkinetic movement disorders …

Abstract L-DOPA-induced dyskinesia (LID) remains a major complication of Parkinson's
disease management for which better therapies are necessary. The contribution of the …

Animal models of Parkinson's disease (PD) are essential to investigate pathogenic
pathways at the whole-organism level. Moreover, they are necessary for a preclinical …

Background Dopamine transmission is involved in the maintenance of the structural
plasticity of direct‐pathway and indirect‐pathway striatal projection neurons (d‐SPNs and i …

Levodopa (L-DOPA) administration remains the gold standard therapy for Parkinson's
disease (PD). Despite several pharmacological advances in the use of L-DOPA, a high …

Evidence shows that altered retinoic acid signaling may contribute to the pathogenesis and
pathophysiology of Parkinson's disease (PD). Retinoic acid is the bioactive derivative of the …