Protein analysis by shotgun/bottom-up proteomics

Y Zhang, BR Fonslow, B Shan, MC Baek… - Chemical …, 2013 - ACS Publications
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Phosphatidylserine: A cancer cell targeting biomarker

B Sharma, SS Kanwar - Seminars in cancer biology, 2018 - Elsevier
Cancer is a leading cause of mortality and morbidity globally. Many prominent cancer-
associated molecules have been identified over the recent years which include EGFR …

The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1

K Unsicker, B Spittau, K Krieglstein - Cytokine & growth factor reviews, 2013 - Elsevier
Abstract GDF-15 (also MIC-1, NAG-1, PLAB, PTGFB) is a member of the TGF-β superfamily,
which is widely distributed in mammalian tissues and has been shown to play multiple roles …

Unravelling the complexity of metastasis—molecular understanding and targeted therapies

N Sethi, Y Kang - Nature Reviews Cancer, 2011 - nature.com
Despite recognizing the devastating consequences of metastasis, we are not yet able to
effectively treat cancer that has spread to vital organs. The inherent complexity of genomic …

On the development of plasma protein biomarkers

S Surinova, R Schiess, R Hüttenhain… - Journal of proteome …, 2011 - ACS Publications
The development of plasma biomarkers has proven to be more challenging than initially
anticipated. Many studies have reported lists of candidate proteins rather than validated …

A label‐free differential proteomics analysis reveals the effect of melatonin on promoting fruit ripening and anthocyanin accumulation upon postharvest in tomato

Q Sun, N Zhang, J Wang, Y Cao, X Li… - Journal of Pineal …, 2016 - Wiley Online Library
To better understand the function of melatonin in tomato fruit ripening and quality
improvement, a label‐free quantitation method was used to investigate the proteins that …

Oral pathogenesis of Aggregatibacter actinomycetemcomitans

P Gholizadeh, A Pormohammad, H Eslami… - Microbial …, 2017 - Elsevier
Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is a Gram-negative,
facultative anaerobic bacillus that causes periodontal diseases such as localized aggressive …

Secretome proteomics for discovery of cancer biomarkers

M Makridakis, A Vlahou - Journal of proteomics, 2010 - Elsevier
“Secretome” is referred to as the rich, complex set of molecules secreted from living cells. In
a less strict definition frequently followed in “secretome” studies, the term also includes …

Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine‐1 in cancer

M Mimeault, SK Batra - Journal of cellular physiology, 2010 - Wiley Online Library
Multifunctional macrophage inhibitory cytokine‐1, MIC‐1, is a member of the transforming
growth factor‐β (TGF‐β) superfamily that plays key roles in the prenatal development and …

MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer

H Zhang, Y Li, Q Huang, X Ren, H Hu… - Cell Death & …, 2011 - nature.com
Apoptosis has a vital role in maintaining tissue homeostasis, and dysregulation of the
apoptotic pathway is now widely recognized as a key step in tumourigenesis. Increasingly …