Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
Immunity to SARS‐CoV‐2 induced by infection or vaccination
Adaptive immune responses play critical roles in viral clearance and protection against re‐
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …
[HTML][HTML] Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
J Liu, J Wang, J Xu, H Xia, Y Wang, C Zhang, W Chen… - Cell Discovery, 2021 - nature.com
Large-scale COVID-19 vaccinations are currently underway in many countries in response
to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies …
to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies …
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin
Mucosal-associated invariant T (MAIT) cells represent an abundant innate-like T cell
subtype in the human liver. MAIT cells are assigned crucial roles in regulating immunity and …
subtype in the human liver. MAIT cells are assigned crucial roles in regulating immunity and …
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical
outcomes ranging from asymptomatic to severe disease and death. We previously reported …
outcomes ranging from asymptomatic to severe disease and death. We previously reported …
[HTML][HTML] Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Immune profiling of COVID-19 patients has identified numerous alterations in both innate
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
M Mabire, P Hegde, A Hammoutene, J Wan… - Nature …, 2023 - nature.com
Recent data have shown that liver fibrosis can regress even at later stages of cirrhosis and
shifting the immune response from pro-inflammatory towards a resolutive profile is …
shifting the immune response from pro-inflammatory towards a resolutive profile is …
[HTML][HTML] Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines
V Mouro, A Fischer - Mucosal immunology, 2022 - Elsevier
The development and deployment of vaccines against COVID-19 demonstrated major
successes in providing immunity and preventing severe disease and death. Yet SARS-CoV …
successes in providing immunity and preventing severe disease and death. Yet SARS-CoV …
[HTML][HTML] MAIT cells, guardians of skin and mucosa?
I Nel, L Bertrand, A Toubal, A Lehuen - Mucosal immunology, 2021 - Elsevier
Abstract Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
ES Ford, K Mayer-Blackwell, L Jing, KJ Laing… - Nature …, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more
protective than vaccination or previous infection alone. To investigate the kinetics of spike …
protective than vaccination or previous infection alone. To investigate the kinetics of spike …