Mechanisms and clinical relevance of bacterial heteroresistance

DI Andersson, H Nicoloff, K Hjort - Nature Reviews Microbiology, 2019 - nature.com
Antibiotic heteroresistance is a phenotype in which a bacterial isolate contains
subpopulations of cells that show a substantial reduction in antibiotic susceptibility …

[HTML][HTML] Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature

K Schwarze, J Buchanan, JC Taylor, S Wordsworth - Genetics in Medicine, 2018 - Elsevier
Purpose We conducted a systematic literature review to summarize the current health
economic evidence for whole-exome sequencing (WES) and whole-genome sequencing …

Clinical use of whole genome sequencing for Mycobacterium tuberculosis

AA Witney, CA Cosgrove, A Arnold, J Hinds, NG Stoker… - BMC medicine, 2016 - Springer
Drug-resistant tuberculosis (TB) remains a major challenge to global health and to
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …

Genome-based prediction of bacterial antibiotic resistance

M Su, SW Satola, TD Read - Journal of clinical microbiology, 2019 - Am Soc Microbiol
Clinical microbiology has long relied on growing bacteria in culture to determine
antimicrobial susceptibility profiles, but the use of whole-genome sequencing for antibiotic …

Whole-genome sequencing of bacterial pathogens: the future of nosocomial outbreak analysis

S Quainoo, JPM Coolen, SAFT van Hijum… - Clinical microbiology …, 2017 - Am Soc Microbiol
Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient
populations in hospitals around the world. Intensive care unit (ICU) patients are particularly …

Methods for the detection and identification of pathogenic bacteria: past, present, and future

L Váradi, JL Luo, DE Hibbs, JD Perry… - Chemical Society …, 2017 - pubs.rsc.org
In order to retard the rate of development of antibacterial resistance, the causative agent
must be identified as rapidly as possible, so that directed patient treatment and/or contact …

Building a tuberculosis-free world: The Lancet Commission on tuberculosis

MJA Reid, N Arinaminpathy, A Bloom, BR Bloom… - The Lancet, 2019 - thelancet.com
Executive summary Tuberculosis can be treated, prevented, and cured. Rapid, sustained
declines in tuberculosis deaths in many countries during the past 50 years provide …

Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing

CRyPTIC Consortium and the 100,000 … - … England Journal of …, 2018 - Mass Medical Soc
Abstract Background The World Health Organization recommends drug-susceptibility testing
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …

Advances in diagnosis of Tuberculosis: an update into molecular diagnosis of Mycobacterium tuberculosis

B Acharya, A Acharya, S Gautam, SP Ghimire… - Molecular biology …, 2020 - Springer
Tuberculosis (TB) is a major cause of deaths by a single infectious agent and has now been
a global public health problem due to increasing numbers of drug-resistant cases. Early and …

Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care

N Dookie, S Rambaran, N Padayatchi… - Journal of …, 2018 - academic.oup.com
Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …