Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Glioma is the most common primary malignant brain tumor with poor survival and limited
therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been …

Durable glioblastoma multiforme (GBM) management requires long‐term chemotherapy
after surgery to eliminate remaining cancerous tissues. Among chemotherapeutics …

Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in
cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Chemoresistance has long been the bottleneck of ovarian cancer (OC) prognosis. It has
been shown that mitochondria play a crucial role in cell response to chemotherapy and that …

Colorectal cancer (CRC) is one of the most common malignancies worldwide and remains a
major clinical challenge. Periplocin, a major bioactive component of the traditional Chinese …

Glioblastoma (GBM) is the most common aggressive malignant tumor in brain
neuroepithelial tumors and remains incurable. A variety of treatment options are currently …