Successful regeneration of large segmental bone defects remains a major challenge in
clinical orthopedics, thus it is of important significance to fabricate a suitable alternative …

Biomedical implants have been widely used in various orthopedic treatments, including total
hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern …

Increased use of reconstruction procedures in orthopedics, due to trauma, tumor, deformity,
degeneration and an aging population, has caused a blossom, not only in surgical …

Hydroxyapatite (HA) is a member of the Ca apatite family. It resembles natural bone in both
structure and chemical composition. HA, owing to its bioactive and biocompatible properties …

A systematic analysis of results available from in vitro, in vivo and clinical trials on the effects
of biocompatible calcium phosphate (CaP) coatings is presented. An overview of the most …

Implants are widely used for orthopaedic applications such as fixing fractures, repairing non-
unions, obtaining a joint arthrodesis, total joint arthroplasty, spinal reconstruction, and soft …

Biomaterial-associated infections occur on both permanent implants and temporary devices
for restoration or support of human functions. Despite increasing use of biomaterials in an …

Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the
mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically …

Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic
loosening and infection are the two most significant causes of prosthetic implant failure. The …

The regeneration of hierarchical osteochondral units is challenging due to difficulties in
inducing spatial, directional and controllable differentiation of mesenchymal stem cells …