Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with
high spatial and temporal resolution. We report variants of intensity-based glutamate …

Neuronal computation is energetically expensive. Consequently, the brain's limited energy
supply imposes constraints on its information processing capability. Most brain energy is …

The past 20 years have resulted in unprecedented progress in understanding brain energy
metabolism and its role in health and disease. In this review, which was initiated at the 14th …

Anatomic and physiologic data are used to analyze the energy expenditure on different
components of excitatory signaling in the grey matter of rodent brain. Action potentials and …

The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

Dendritic spines serve as preferential sites of excitatory synaptic connections and are
pleomorphic. To address the structure–function relationship of the dendritic spines, we used …

1. Dual voltage recordings were made from pairs of adjacent, synaptically connected thick
tufted layer 5 pyramidal neurones in brain slices of young rat (14‐16 days) somatosensory …

Synapse regulation exploits the capacity of actin to function as a stable structural component
or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological …