The decline in cognitive function and the prevalence of neurodegenerative disorders are
among the most serious threats to health in old age. The prevalence of dementia has …

Benzodiazepines (BZDs) and Z-drugs are compounds widely prescribed in medical practice
due to their anxiolytic, hypnotic, and muscle relaxant properties. Yet, their chronic use is …

Insulin resistance associates with increased risk for cognitive decline and dementia;
however, the underpinning mechanisms for this increased risk remain to be fully defined. As …

Introduction Few studies have examined memory decline among patients with type 2
diabetes using different oral hypoglycemic drugs. Methods Participants with normal …

Background: Type 2 diabetes (T2D) is a risk factor for cognitive dysfunction. The relationship
between metformin therapy and cognitive function in patients with T2D is unknown …

Metabolic syndrome (MS) is a set of cardio-metabolic risk factors that includes central
obesity, hyperglycemia, hypertension, and dyslipidemias. The syndrome affects 25% of …

Cognitive impairment is a shared abnormality between type 2 diabetes mellitus (T2DM) and
many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease (AD) …

Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly,
plays a complex role in multiple physiological and pathophysiological processes by …

It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted.
Its endocrine functions came first to light when it was realized that osteoblasts, the bone …

The objective of this study was to evaluate the relation of metformin with change in cognition
and brain pathology. During a mean of 8 years (SD= 5.5) of annual follow-up visits …