Ulcerative colitis (UC) has been characterized by inflammation limited to the mucosa.
Although sustained and durable remission has been associated with mucosal healing, the …

The nuclear long non-coding RNA LUCAT1 has previously been identified as a negative
feedback regulator of type I interferon and inflammatory cytokine expression in human …

This study reveals a previously uncharacterized mechanism to restrict intestinal
inflammation via a regulatory RNA transcribed from a noncoding genomic locus. We …

Abstract Background Anemoside B4 (AB4) is reported to prevent acute colitis when given via
intraperitoneal injection by two recent studies. However, whether oral AB4 protects against …

Inflammatory bowel diseases are a conglomerate of disorders causing inflammation of the
gastrointestinal tract, which have gained a significant increase in prevalence in the 21st …

Background and Objectives: Ulcerative Colitis (UC) subtypes defined by disease extent and
shared pathophysiology are important. Analyzing the clinical characteristics of UC with …

Personalized care in inflammatory bowel diseases (IBD) hinges on parsing the
heterogeneity of IBD patients through prognostication of their disease course and …

Precision medicine is part of 5 focus areas of the Challenges in IBD Research 2024
research document, which also includes preclinical human IBD mechanisms, environmental …

Inflammation is the most common biological occurrence in any living organism's life, and it
can be both beneficial and harmful. Under homeostatic conditions inflammation is finely …

ABSTRACT Introduction Approximately 20-30% of patients with ulcerative colitis (UC) may
present with isolated proctitis. Ulcerative proctitis (UP) is a challenging condition to manage …