In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in
tumor initiation and progression, shaped by complex interactions between cancer cells and …

Immune checkpoint blockade therapy has revolutionized the field of cancer treatment,
leading to durable responses in patients with advanced and metastatic cancers where …

Chronic inflammation is recognized as a major risk factor for cancer and is involved in every
phase of the disease. Inflammasomes are central to the inflammatory response and play a …

Cell death is a fundamental part of life for metazoans. To maintain the balance between cell
proliferation and metabolism of human bodies, a certain number of cells need to be removed …

Glioblastoma multiforme (GBM) is the most therapeutically challenging primary brain tumor
owing to the unique physiological structure of the blood–brain barrier. Lately, research on …

Pyroptosis is a novel regulated cell death (RCD) mode associated with inflammation and
innate immunity. Gasdermin E (GSDME), a crucial component of the gasdermin (GSDM) …

Pyroptosis is an inflammatory programed cell death process that plays a crucial role in
cancer therapeutic, while Gasdermin-D is a critical effector protein for pyroptosis execution …

Introduction Over the past two years, the scientific community has witnessed an exponential
growth in research focused on identifying prognostic biomarkers for melanoma, both in pre …

The gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, a process critical to
the body's immune response, particularly in combatting bacterial infections, impeding tumor …

Gliomas are prevalent malignant tumors in adults, which can be categorized as either
localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of …