Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …

The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …

Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and
plays important roles in the viral life cycle. Being a large, multidomain, transmembrane …

Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

Inflammation is the body's response to danger. One of the first immune cell types to
encounter danger is the macrophage. Macrophages sense danger signals such as …

Coronavirus has brought about three massive outbreaks in the past two decades. Each step
of its life cycle invariably depends on the interactions among virus and host molecules. The …

Regarding the crucial role of deubiquitinase (DUB) enzymes in many viruses, in particular,
Adenovirus, HSV-1, coxsackievirus, and SARS-CoV-2, DUB inhibition was reported as an …

Distinct families of eukaryotic deubiquitinases (DUBs) are regulators of ubiquitin signaling.
Here, we report on the presence of an additional DUB class broadly distributed in …

ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the
LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The …