To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics,
display remarkable heterogeneity in structure and function. This is the second of a 2-part …

A normal hemostatic response to vascular injury requires both factor VIII (FVIII) and von
Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent …

Abstract Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …

The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with
contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo …

The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many
coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been …

(1) Background: The current outbreak of COVID-19 infection is an ongoing challenge and a
major threat to public health that requires surveillance, prompt diagnosis, as well as …

The interaction of factor VIII (FVIII) with von Willebrand Factor (VWF) is of direct clinical
significance in the diagnosis and treatment of patients with haemophilia A and von …

Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when
combined, make them ideally suited for cellular-based immunotherapy and as vehicles for …

Abstract von Willebrand factor (VWF) is a large multimeric adhesive glycoprotein with
complex roles in thrombosis and hemostasis. Abnormalities in VWF give rise to a variety of …