Role of manganese in neurodegenerative diseases
Manganese (Mn) is an essential ubiquitous trace element that is required for normal growth,
development and cellular homeostasis. Exposure to high Mn levels causes a clinical …
development and cellular homeostasis. Exposure to high Mn levels causes a clinical …
Metal ions as modulators of protein conformation and misfolding in neurodegeneration
Protein misfolding and conformational changes are a cornerstone of neurodegenerative
diseases involving formation and deposition of toxic protein oligomers. Although mutations …
diseases involving formation and deposition of toxic protein oligomers. Although mutations …
Different species of α-synuclein oligomers induce calcium influx and seeding
KM Danzer, D Haasen, AR Karow… - Journal of …, 2007 - Soc Neuroscience
Aggregation of α-synuclein (α-syn) has been linked to the pathogenesis of Parkinson's
disease (PD) and other neurodegenerative diseases. Increasing evidence suggests that …
disease (PD) and other neurodegenerative diseases. Increasing evidence suggests that …
[HTML][HTML] Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies
A Samsel, S Seneff - Surgical neurology international, 2015 - ncbi.nlm.nih.gov
Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for
multiple essential functions in the body. A recent study on cows fed genetically modified …
multiple essential functions in the body. A recent study on cows fed genetically modified …
Single particle characterization of iron-induced pore-forming α-synuclein oligomers
Aggregation of α-synuclein is a key event in several neurodegenerative diseases, including
Parkinson disease. Recent findings suggest that oligomers represent the principal toxic …
Parkinson disease. Recent findings suggest that oligomers represent the principal toxic …
Copper (II) inhibits in vitro conversion of prion protein into amyloid fibrils
In recent studies, the amyloid fibrils produced in vitro from recombinant prion protein
encompassing residues 89− 230 (rPrP 89− 230) were shown to produce transmissible form …
encompassing residues 89− 230 (rPrP 89− 230) were shown to produce transmissible form …
Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
L Breydo, VN Uversky - Metallomics, 2011 - academic.oup.com
Neurodegenerative diseases constitute a set of pathological conditions originating from the
slow, irreversible, and systematic cell loss within the various regions of the brain and/or the …
slow, irreversible, and systematic cell loss within the various regions of the brain and/or the …
Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape
The timescale for the microscopic dynamics of proteins during conformational transitions is
set by the intrachain diffusion coefficient, D. Despite the central role of protein misfolding and …
set by the intrachain diffusion coefficient, D. Despite the central role of protein misfolding and …
The expanding universe of prion diseases
JC Watts, A Balachandran, D Westaway - PLoS pathogens, 2006 - journals.plos.org
Prions cause fatal and transmissible neurodegenerative disease. These etiological
infectious agents are formed in greater part from a misfolded cell-surface protein called …
infectious agents are formed in greater part from a misfolded cell-surface protein called …
Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis
M Duering, A Karpinska, S Rosner… - Human molecular …, 2011 - academic.oup.com
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy) is the most common monogenic cause of stroke and vascular …
leukoencephalopathy) is the most common monogenic cause of stroke and vascular …