The current state of oncolytic herpes simplex virus for glioblastoma treatment
HM Nguyen, D Saha - Oncolytic Virotherapy, 2021 - Taylor & Francis
Glioblastoma (GBM) is a lethal primary malignant brain tumor with no current effective
treatments. The recent emergence of immuno-virotherapy and FDA approval of T-VEC have …
treatments. The recent emergence of immuno-virotherapy and FDA approval of T-VEC have …
Antiangiogenic therapy for malignant brain tumors: does it still Matter?
A Pellerino, F Bruno, R Soffietti, R Rudà - Current Oncology Reports, 2023 - Springer
Abstract Purpose of Review To summarize the mechanisms of tumor angiogenesis and
resistance to antiangiogenic therapy, and the influence on tumor microenvironment. Recent …
resistance to antiangiogenic therapy, and the influence on tumor microenvironment. Recent …
Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study
C Jiguet-Jiglaire, S Boissonneau, E Denicolai… - Acta Neuropathologica …, 2022 - Springer
We previously identified matrix metalloproteinase 2 (MMP2) and MMP9 plasma levels as
candidate biomarkers of bevacizumab activity in patients with recurrent glioblastoma. The …
candidate biomarkers of bevacizumab activity in patients with recurrent glioblastoma. The …
GBM-targeted oHSV armed with matrix metalloproteinase 9 enhances anti-tumor activity and animal survival
P Sette, N Amankulor, A Li, M Marzulli… - Molecular Therapy …, 2019 - cell.com
The use of mutant strains of oncolytic herpes simplex virus (oHSV) in early-phase human
clinical trials for the treatment of glioblastoma multiforme (GBM) has proven safe, but limited …
clinical trials for the treatment of glioblastoma multiforme (GBM) has proven safe, but limited …
Effects of oncolytic viruses and viral vectors on immunity in glioblastoma
P Liu, Y Wang, Y Wang, Z Kong, W Chen, J Li, W Chen… - Gene Therapy, 2022 - nature.com
Glioblastoma (GBM) is regarded as an incurable disease due to its poor prognosis and
limited treatment options. Virotherapies were once utilized on cancers for their oncolytic …
limited treatment options. Virotherapies were once utilized on cancers for their oncolytic …
A vasculature-centric approach to developing novel treatment options for glioblastoma
HG Wirsching, P Roth, M Weller - Expert Opinion on Therapeutic …, 2021 - Taylor & Francis
Introduction: Glioblastoma is invariably deadly and is characterized by extensive
vascularization and macrophage-dominant immunosuppression; nevertheless, anti …
vascularization and macrophage-dominant immunosuppression; nevertheless, anti …
Leveraging the replication‐competent avian‐like sarcoma virus/tumor virus receptor‐A system for modeling human gliomas
Gliomas are the most common primary intrinsic brain tumors occurring in adults. Of all
malignant gliomas, glioblastoma (GBM) is considered the deadliest tumor type due to diffuse …
malignant gliomas, glioblastoma (GBM) is considered the deadliest tumor type due to diffuse …
The complex relationship between integrins and oncolytic herpes Simplex Virus 1 in high-grade glioma therapeutics
High-grade gliomas (HGGs) are lethal central nervous system tumors that spread quickly
through the brain, making treatment challenging. Integrins are transmembrane receptors that …
through the brain, making treatment challenging. Integrins are transmembrane receptors that …