Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with
particularly high evolutionary conservation of ligand binding domain. The receptor exists in …

Signal transducer and activator of transcription (STAT) 3 and STAT5 are important
transcription factors that are able to mediate or even drive cancer progression through …

The constitutive activation of Janus Kinase/Signal Transducer and Activator of Transcription
(JAK/STAT) signal transduction is well elucidated in STAT3-mediated oncogenesis related …

Retinoid X receptors (RXRs) control a wide variety of functions by virtue of their dimerization
with other nuclear hormone receptors (NRs), contributing thereby to activities of different …

Colorectal cancer (CRC) ranks as the third most aggressive tumor globally, and it can be
categorized into two forms: colitis-mediated CRC and sporadic CRC. The therapeutic …

Tumor-associated angiogenesis is a key target for anti-cancer therapy. The imbalance
between pro-angiogenic and anti-angiogenic signals elicited by tumor cells or tumor …

Cancer occurs in a complex tissue environment, and its progression depends largely on the
tumour microenvironment (TME). The TME has a highly complex and comprehensive system …

An imbalance in the production of reactive oxygen species in the body can cause an
increase of oxidative stress that leads to oxidative damage to cells and tissues, which …

Apoptosis is a programmed cell death comprising two signaling cascades including the
intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy …

The pharmacological effects of natural product therapy have received sigificant attention,
among which terpenoids such as sesquiterpene lactones stand out due to their biological …