Biology and biomechanics of the heart valve extracellular matrix
KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
[HTML][HTML] Heart valve biomechanics and underlying mechanobiology
Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They
have a remarkable ability to withstand the demanding mechanical environment of the heart …
have a remarkable ability to withstand the demanding mechanical environment of the heart …
Characterizing white matter tissue in large strain via asymmetric indentation and inverse finite element modeling
Characterizing the mechanical properties of white matter is important to understand and
model brain development and injury. With embedded aligned axonal fibers, white matter is …
model brain development and injury. With embedded aligned axonal fibers, white matter is …
A coupled mitral valve—left ventricle model with fluid–structure interaction
Understanding the interaction between the valves and walls of the heart is important in
assessing and subsequently treating heart dysfunction. This study presents an integrated …
assessing and subsequently treating heart dysfunction. This study presents an integrated …
On the simulation of mitral valve function in health, disease, and treatment
The mitral valve (MV) is the left atrioventricular heart valve that regulates blood flow between
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …
An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets
The facilitation of proper blood flow through the heart depends on proper function of heart
valve components, and alterations to any component can lead to heart disease or failure …
valve components, and alterations to any component can lead to heart disease or failure …
A meso-scale layer-specific structural constitutive model of the mitral heart valve leaflets
Fundamental to developing a deeper understanding of pathophysiological remodeling in
mitral valve (MV) disease is the development of an accurate tissue-level constitutive model …
mitral valve (MV) disease is the development of an accurate tissue-level constitutive model …
On the effects of leaflet microstructure and constitutive model on the closing behavior of the mitral valve
Recent long-term studies showed an unsatisfactory recurrence rate of severe mitral
regurgitation 3–5 years after surgical repair, suggesting that excessive tissue stresses and …
regurgitation 3–5 years after surgical repair, suggesting that excessive tissue stresses and …
Mechanics of the tricuspid valve—From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling
Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …
Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture …
Collagen fiber networks provide the structural strength of tissues, such as tendons, skin and
arteries. Quantifying the fiber architecture in response to mechanical loads is essential …
arteries. Quantifying the fiber architecture in response to mechanical loads is essential …