Objective: To evaluate the diagnostic accuracy of clinical diagnosis of Parkinson disease
(PD) reported in the last 25 years by a systematic review and meta-analysis. Methods: We …

Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …

The diagnosis of Parkinson's disease (PD) and atypical parkinsonian syndromes is difficult
due to the lack of reliable, easily accessible biomarkers. Multiple system atrophy (MSA) is a …

Background The accumulation of misfolded α‐synuclein aggregates is associated with PD.
However, the diagnostic value of the α‐synuclein levels in CSF is still under investigation …

Network analytical tools are increasingly being applied to brain imaging maps of resting
metabolic activity (PET) or blood oxygenation-dependent signals (functional MRI) to …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Background Clinical diagnostic accuracy of Parkinson's disease (PD) remains suboptimal.
Changes in disease concept may have improved clinical diagnostic accuracy in the past …

Background Extracellular vesicles are small vesicles that are released from many cells,
including neurons. α‐Synuclein has recently been described in extracellular vesicles …

Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders,
particularly in the early stages of the disease. An autonomic-only presentation can be …

Parkinson's disease (PD) biomarkers are needed by both clinicians and researchers (for
diagnosis, identifying study populations, and monitoring therapeutic response). Imaging …