Oestradiol as a neuromodulator of learning and memory

LR Taxier, KS Gross, KM Frick - Nature Reviews Neuroscience, 2020 - nature.com
Although hormones such as glucocorticoids have been broadly accepted in recent decades
as general neuromodulators of memory processes, sex steroid hormones such as the potent …

Estrogen receptors and the aging brain

S Maioli, K Leander, P Nilsson… - Essays in Biochemistry, 2021 - portlandpress.com
The female sex hormone estrogen has been ascribed potent neuroprotective properties. It
signals by binding and activating estrogen receptors that, depending on receptor subtype …

Estrogen synthesis and signaling pathways during aging: from periphery to brain

J Cui, Y Shen, R Li - Trends in molecular medicine, 2013 - cell.com
Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

The peri-menopause in a woman's life: a systemic inflammatory phase that enables later neurodegenerative disease

M McCarthy, AP Raval - Journal of neuroinflammation, 2020 - Springer
The peri-menopause or menopausal transition—the time period that surrounds the final
years of a woman's reproductive life—is associated with profound reproductive and …

Estrogen effects on cognitive and synaptic health over the lifecourse

Y Hara, EM Waters, BS McEwen… - Physiological …, 2015 - journals.physiology.org
Estrogen facilitates higher cognitive functions by exerting effects on brain regions such as
the prefrontal cortex and hippocampus. Estrogen induces spinogenesis and synaptogenesis …

[HTML][HTML] Role of estrogen and other sex hormones in brain aging. Neuroprotection and DNA repair

S Zárate, T Stevnsner, R Gredilla - Frontiers in aging neuroscience, 2017 - frontiersin.org
Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …

Estrogen: a master regulator of bioenergetic systems in the brain and body

JR Rettberg, J Yao, RD Brinton - Frontiers in neuroendocrinology, 2014 - Elsevier
Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial …

Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females

A Almey, TA Milner, WG Brake - Hormones and behavior, 2015 - Elsevier
This article is part of a Special Issue “Estradiol and cognition”. Over the past 30 years,
research has demonstrated that estrogens not only are important for female reproduction …

Sex differences in the brain: Implications for behavioral and biomedical research

E Choleris, LAM Galea, F Sohrabji, KM Frick - … & Biobehavioral Reviews, 2018 - Elsevier
Biological differences between males and females are found at multiple levels. However,
females have too often been under-represented in behavioral neuroscience research, which …

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

KM Frick, J Kim, JJ Tuscher, AM Fortress - Learning & Memory, 2015 - learnmem.cshlp.org
Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen
17β-estradiol (E2), affect hippocampal morphology, plasticity, and memory in male and …