Lysosomes support diverse cellular functions by acting as sites of macromolecule
degradation and nutrient recycling. The degradative abilities of lysosomes are conferred by …

Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world. With the advent of an aging population and improving life expectancy worldwide, the …

VPS13 proteins are proposed to function at contact sites between organelles as bridges for
lipids to move directionally and in bulk between organellar membranes. VPS13s are …

Mutations in VPS13C cause early-onset, autosomal recessive Parkinson's disease (PD). We
have established that VPS13C encodes a lipid transfer protein localized to contact sites …

Parkinson's disease (PD) is a neurodegenerative disorder involving the loss of
dopaminergic neurons in the brain. Following the discovery of the PD-causing D620N …

A recent large-scale European-originated genome-wide association data meta-analysis
followed by a replication study identified 6 new risk loci for Parkinson's disease (PD), which …

Introduction Family based study designs provide an informative resource to identify disease-
causing mutations. The Queensland Parkinson's Project (QPP) has been involved in …

Mitochondrial damage is associated with the development of Parkinson's disease (PD),
indicating that mitochondrial‐targeted treatments could hold promise as disease‐modifying …

DNAJC6 has been reported as a causative gene for early onset Parkinson's disease (EOPD)
in some populations, and different mutations have been reported to be associated with …

The protein α-synuclein (α-syn) is one of the major factors linked to Parkinson's disease, yet
how its misfolding and deposition contribute to the pathology remains largely elusive …