The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …

Objective: During the past decades, increasing efforts have been invested in studies to
unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response …

Background Antipsychotics have been linked to prolongation of the QT interval. However,
little is known about the risk of ventricular arrhythmia (VA) and/or sudden cardiac death …

The SLC22 family of OATs, OCTs, and OCTNs is emerging as a central hub of endogenous
physiology. Despite often being referred to as “drug” transporters, they facilitate the …

Breast cancer is characterized by the uncontrolled proliferation of breast cells, with a high
incidence reported in 2020 to have affected over 2 million women. In recent years, the …

Considerable progress has been made in identifying genetic risk factors for idiosyncratic
adverse drug reactions in the past 30 years. These reactions can affect various tissues and …

A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden
cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for …

Cardiovascular morbidity and mortality are important problems among patients with
schizophrenia. A wide spectrum of reasons, ranging from genes to the environment, are held …

Although sequencing a single human genome was a monumental effort a decade ago, more
than 1000 genomes have now been sequenced. The task ahead lies in transforming this …

This review presents the findings of pharmacogenetic studies exploring the influence of
gene variants on antipsychotic treatment response, in terms of both symptom improvement …