Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human
pathogen that results in mucocutaneous lesions in the oral cavity or genital infections …

The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

Lethal mutagenesis has emerged as a novel potential therapeutic approach to treat viral
infections. Several studies have demonstrated that increases in the high mutation rates …

Background & Aims Ribavirin monotherapy is the preferred treatment for chronic hepatitis E,
although occasional treatment failure occurs. We present a patient with chronic hepatitis E …

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …

Favipiravir is an important selective antiviral against RNA-based viruses, and currently, it is
being repurposed as a potential drug for the treatment of COVID-19. This type of chemical …

Highlights•A broad spectrum antiviral effective against virtually all viruses tested in
vitro.•Mechanism of action varies with virus and cell type.•Virus resistance often involves …

Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an
excess of mutations acquired during replication in the presence of a mutagen. Here we …

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …

Passage of hepatitis C virus (HCV) in human hepatoma cells resulted in populations that
displayed partial resistance to alpha interferon (IFN-α), telaprevir, daclatasvir, cyclosporine …