Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

A general approach to 3‐azabicyclo [3.1. 1] heptanes by reduction of spirocyclic oxetanyl
nitriles was developed. The mechanism, scope, and scalability of this transformation were …

Abstract Synthesis of previously unavailable 1, 2‐disubstituted cyclobutane building blocks
bearing mono‐, di‐and trifluoromethyl groups are disclosed. The key steps included …

Synthesis of amino acids with isolated saturated (hetero) carbocyclic scaffold was disclosed.
The method relied on Suzuki cross-coupling reaction of heteroacycloalkene triflates and N …

An efficient approach to the multigram synthesis of 3‐azabicyclo [3.1. 1] heptanes is
described. The method relied on the intramolecular imide formation in the properly 1, 3 …

A gram‐scale synthesis, physico‐chemical characterization, and lead‐likeness assessment
of 4‐di/trifluoromethyl‐2‐heterabicyclo [2.1. 1] hexanes as fluorinated bicyclic proline …

A general approach to 3-azabicyclo [3.1. 1] heptanes was unexpectedly discovered. The
mechanism, scope, and scalability of this method were studied. The core was incorporated …

Synthesis of monoprotected diamines derived from 1, 5‐disubstituted spiro [2.3] hexane and
5‐azaspiro [2.3] hexane scaffolds is described. In both cases, the method relied on the …

Актуальность темы исследования. Одним из современных подходов к исследованию
пространственной структуры биомакромолекул (белков, нуклеиновых кислот, их …

Four new cyclobutane-containing building blocks were synthesized on a multigram scale
starting from 3-methylene-1-(trifluoromethyl) cyclobutane-1-carbonitrile and 3-methylene-1 …