In vitro and in vivo preclinical evaluation of a minisphere emulsion-based formulation (SmPill®) of salmon calcitonin
TAS Aguirre, M Rosa, IS Coulter, DJ Brayden - European Journal of …, 2015 - Elsevier
Abstract Salmon calcitonin (sCT, MW 3432 Da) is a benchmark molecule for an oral peptide
delivery system because it is degraded and has low intestinal epithelial permeability. Four …
delivery system because it is degraded and has low intestinal epithelial permeability. Four …
Coated minispheres of salmon calcitonin target rat intestinal regions to achieve systemic bioavailability: Comparison between intestinal instillation and oral gavage
TAS Aguirre, V Aversa, M Rosa, SS Guterres… - Journal of Controlled …, 2016 - Elsevier
Achieving oral peptide delivery is an elusive challenge. Emulsion-based minispheres of
salmon calcitonin (sCT) were synthesized using single multiple pill (SmPill®) technology …
salmon calcitonin (sCT) were synthesized using single multiple pill (SmPill®) technology …