Local or systemic inflammation can severely impair urinary bladder functions and contribute
to the development of voiding disorders in millions of people worldwide. Isoprostanes are …

The influence of extracellular and intracellular calcium on smooth muscle contractile activity
varies between organs. In response to G protein-coupled receptor (GPCR) stimulation, the …

Botulinum neurotoxin (BoNT/A) is an FDA and NICE approved second-line treatment for
overactive bladder (OAB) in patients either not responsive or intolerant to anti-cholinergic …

The transitional epithelial cells (urothelium) that line the lumen of the urinary bladder form a
barrier between potentially harmful pathogens, toxins, and other bladder contents and the …

Abstract Ethnopharmacological relevance Suo-Quan-Wan (SQW), a traditional Chinese
prescription, has been used for hundreds of years to alleviate overactive bladder (OAB) …

Uterine injury from procedures such as Cesarean sections (C-sections) often have severe
consequences on subsequent pregnancy outcomes, leading to disorders such as placenta …

Current pharmacological treatment options for many bladder contractile dysfunctions are not
suitable for all patients, thereby bringing interest to the investigation of therapies that target a …

The inner lining of the urinary bladder (urothelium and lamina propria, or bladder mucosa)
has an important role as a tissue barrier between stored urine and the underlying smooth …

Aims We examined the potential stimulatory effects of U46619 (a prostanoid TP receptor
agonist) and five prostanoids on the contractile activities of urinary bladder smooth muscle …

Purpose Bladder ischemia/reperfusion is an important etiologic factor for overactive bladder
disease. The occurrence of this disease is closely associated with enhanced spontaneous …