The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …

The Notch signaling pathway regulates many aspects of cancer biology. Most attention has
been given to its role in the transformed cell. However, it is now clear that cancer …

The vasculature of tumours is highly abnormal and dysfunctional. Consequently, immune
effector cells have an impaired ability to penetrate solid tumours and often exhibit …

The recent approval of Provenge has brought new hope for anticancer vaccine therapies.
However, the immunosuppressive tumor microenvironment seems to impair the efficacy of …

Evolutionarily conserved Notch plays a critical role in embryonic development and cellular
self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is …

Multiple effector layers in the immune system ensure an optimal temporal and spatial
distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive …

Notch signaling pathway mediates cell-fate determination during embryonic development,
wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the …

Adoptive transfer of naturally occurring or genetically engineered T cells is an effective
treatment for certain haematological malignancies, such as non-Hodgkin lymphoma and …

The Notch signaling pathway regulates important cellular processes involved in stem cell
maintenance, proliferation, development, survival, and inflammation. These responses to …