This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is …

The treatment of acute ischemic stroke has undergone dramatic changes recently
subsequent to the demonstrated efficacy of intra-arterial (IA) device-based therapy in …

Ischemic stroke is a devastating disease with a complex pathophysiology. Animal modeling
of ischemic stroke serves as an indispensable tool first to investigate mechanisms of …

Acute ischaemic stroke accounts for 6.5 million deaths per year, and by 2030 will result in
the annual loss of over 200 million disability-adjusted life years globally. There have been …

Stroke seriously threatens human health because of its characteristics of high morbidity,
disability, recurrence, and mortality, thus representing a heavy financial and mental burden …

A variety of animal models have been developed for modeling ischemic stroke. The middle
cerebral artery occlusion (MCAO) model has been utilized extensively, especially in rodents …

Middle cerebral artery occlusion (MCAO) in rats is a well-studied experimental model for
ischemic stroke leading to brain infarction and functional deficits. Many preclinical studies …

Stroke continues to be a significant cause of death and disability worldwide. Although major
advances have been made in the past decades in prevention, treatment, and rehabilitation …

Stroke is a condition with few medical treatments available. Semaglutide, a novel Glucagon-
like peptide-1 (GLP-1) analogue, has been brought to the market as a treatment for diabetes …

Brain swelling is one of the most robust predictors of outcome following brain injury,
including ischemic, traumatic, hemorrhagic, metabolic or other injury. Depending on the …