An extensive body of literature describes anticancer property of dichloroacetate (DCA), but
its effective clinical administration in cancer therapy is still limited to clinical trials. The …

We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational
treatment for various acquired and congenital disorders of mitochondrial intermediary …

Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …

Cancer remains a lethal threat to global lives. Development of novel anticancer therapeutics
is still a challenge to scientists in the field of biomedicine. In cancer cells, the metabolic …

Aerobic glycolysis, ie., the Warburg effect, may contribute to the aggressive phenotype of
hepatocellular carcinoma. However, increasing evidence highlights the limitations of the …

Cholangiocarcinoma (CCA), a devastating cancer with a poor prognosis, is resistant to the
currently available chemotherapeutic agents. Capsaicin, the major pungent ingredient found …

The activation of immune cells in response to stimuli present in their microenvironment is
regulated by their metabolic profile. Unlike the signal transduction events, which overlap to a …

Recent evidence suggests that anti-diabetic drug metformin prevents cancer progression,
but the mechanism by which metformin inhibits tumor growth remains elusive. In this study …

Background Glioblastoma (GBM) is the most common and malignant primary brain tumor. In
contrast to some other tumor types, aberrant glucose metabolism is an important component …

While normal differentiated cells primarily use mitochondrial respiration to generate the
required energy for cellular processes, most cancer cells rely on glycolysis, even in sufficient …