The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …

Background The disease course of amyotrophic lateral sclerosis (ALS) is rapid and,
because its pathophysiology is unclear, few effective treatments are available. Genetic …

This article presents the revised consensus criteria for the diagnosis of frontotemporal
dysfunction in amyotrophic lateral sclerosis (ALS) based on an international research …

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder affecting
motor neurons, resulting in progressive muscle weakness and death by respiratory failure …

The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Glaucoma is defined by characteristic optic nerve damage and corresponding visual field
defects and is the leading cause of irreversible blindness in the world. Elevated intraocular …

Frontotemporal lobar degeneration (FTLD) represents a group of neurodegenerative brain
diseases with highly heterogeneous clinical, neuropathological and genetic characteristics …

Amyotrophic lateral sclerosis and frontotemporal dementia are two progressive, adult onset
neurodegenerative diseases, caused by the cell death of motor neurons in the motor cortex …

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by
progressive changes in behavior, personality, and language with involvement of the frontal …

Background There is a lack of effective therapeutic strategies for amyotrophic lateral
sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the …