[HTML][HTML] Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid dispersions
A Saberi, M Kouhjani, D Yari, A Jahani… - Journal of Drug Delivery …, 2023 - Elsevier
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …
Ternary Solid Dispersions: A Review of the Preparation, Characterization, Mechanism of Drug Release, and Physical Stability
A Budiman, E Lailasari, NV Nurani, EN Yunita… - Pharmaceutics, 2023 - mdpi.com
The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has
experienced a significant increase in recent years. These APIs present challenges in …
experienced a significant increase in recent years. These APIs present challenges in …
Thermodynamic aspects of the preparation of amorphous solid dispersions of Naringenin with enhanced dissolution rate
Amorphous ternary solid dispersions of poorly water-soluble Naringenin (NRG) in
Poloxamer 188 (POX) and Neusilin US2 (NSL) were prepared in a Hot-Melt Extruder (HME) …
Poloxamer 188 (POX) and Neusilin US2 (NSL) were prepared in a Hot-Melt Extruder (HME) …
Binary polymeric amorphous carvedilol solid dispersions: In vitro and in vivo characterization
M Krstić, L Manić, N Martić, D Vasiljević… - European Journal of …, 2020 - Elsevier
Binary polymeric amorphous carvedilol solid dispersions were prepared using solvent
method by varying solvent type, polymer type and carvedilol to polymer ratio in order to …
method by varying solvent type, polymer type and carvedilol to polymer ratio in order to …
Crystallization and intermolecular hydrogen bonding in carbamazepine-polyvinyl pyrrolidone solid dispersions: An experiment and molecular simulation study on drug …
H Wang, Y Luan, M Li, S Wu, S Zhang, J Xue - International Journal of …, 2024 - Elsevier
The choice of drug content is a critical factor as far as the solid dispersion is concerned. This
investigation aims to build the relationship between the drug content, intermolecular …
investigation aims to build the relationship between the drug content, intermolecular …
Design and characterization of phosphatidylcholine-based solid dispersions of aprepitant for enhanced solubility and dissolution
S Yeo, J An, C Park, D Kim, J Lee - Pharmaceutics, 2020 - mdpi.com
This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor
aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system. When …
aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system. When …
How Does the Addition of Kollidon®VA64 Inhibit the Recrystallization and Improve Ezetimibe Dissolution from Amorphous Solid Dispersions?
J Szafraniec-Szczęsny, A Antosik-Rogóż, M Kurek… - Pharmaceutics, 2021 - mdpi.com
Amorphization serves as a strategy for the improvement of poor dissolution characteristics of
many drug compounds. However, in many formulations the content of polymeric stabilizer is …
many drug compounds. However, in many formulations the content of polymeric stabilizer is …
Amalgamation of solid dispersion and melt adsorption techniques for augmentation of oral bioavailability of novel anticoagulant rivaroxaban
The objective of the present study was to evaluate the potential of solid dispersion adsorbate
(SDA) to improve the solubility and bioavailability of rivaroxaban (RXN). SDA of RXN was …
(SDA) to improve the solubility and bioavailability of rivaroxaban (RXN). SDA of RXN was …
Improved drug transfer into brain tissue via the “nose-to-brain” approach using suspension or powder formulations based on the amorphous solid dispersion …
S Suwabe, T Tagami, K Ogawa, T Ozeki - European Journal of …, 2023 - Elsevier
Intranasal administration has attracted increasing attention as a drug delivery approach
based on nose-to-brain drug delivery from the nasal cavity to brain tissue directly, bypassing …
based on nose-to-brain drug delivery from the nasal cavity to brain tissue directly, bypassing …
Design, formulation and evaluation of multiparticulate time programmed system of ramipril for pulsed release: An approach in the management of early morning surge …
SK Roy, P Das, A Mondal, A Mandal… - Journal of Drug Delivery …, 2021 - Elsevier
The intent of the present study was to develop and evaluate multiparticulate pulsatile
release system from the solid dispersion of ramipril to minimize the risk of cardiovascular …
release system from the solid dispersion of ramipril to minimize the risk of cardiovascular …