The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

Improvements in whole genome amplification (WGA) would enable new types of basic and
applied biomedical research, including studies of intratissue genetic diversity that require …

The inherent heterogeneity in cell populations has become of great interest and importance
as analytical techniques have improved over the past decades. With the advent of …

Advances in population-scale genomic sequencing have greatly expanded the
understanding of the inherited basis of cardiovascular disease (CVD). Reanalysis of these …

Prolonged QT intervals are a major risk factor for ventricular arrhythmias and a leading
cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation …

Long QT syndrome (LQTS) is a cardiac electrophysiologic disorder, characterized by QT
prolongation and T-wave abnormalities on the EKG that are associated with …

From conception to death, human cells accumulate somatic mutations in their genomes.
These mutations can contribute to the development of cancer and non-malignant diseases …

High-throughput sequencing has ushered in a diversity of approaches for identifying genetic
variants and understanding genome structure and function. When applied to individuals with …