Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y Xie, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

[HTML][HTML] Exploration of pattern recognition receptor agonists as candidate adjuvants

GH Ong, BSX Lian, T Kawasaki… - Frontiers in cellular and …, 2021 - frontiersin.org
Adjuvants are used to maximize the potency of vaccines by enhancing immune reactions.
Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and …

[HTML][HTML] SARS-CoV-2 mRNA vaccines elicit different responses in immunologically naïve and pre-immune humans

D Forgacs, H Jang, RB Abreu, HB Hanley… - Frontiers in …, 2021 - frontiersin.org
As the COVID-19 pandemic continues, the authorization of vaccines for emergency use has
been crucial in slowing down the rate of infection and transmission of the SARS-CoV-2 virus …

[HTML][HTML] Safety and immunogenicity of the GamTBvac, the recombinant subunit tuberculosis vaccine candidate: a phase II, multi-center, double-blind, randomized …

AP Tkachuk, EN Bykonia, LI Popova, DA Kleymenov… - Vaccines, 2020 - mdpi.com
GamTBvac is a candidate tuberculosis vaccine with two fusion proteins, containing Ag85a,
ESAT6, CFP10, and a dextran-binding domain (DBD). Phase II of a double-blind …

[HTML][HTML] First-in-human trials of GamTBvac, a recombinant subunit tuberculosis vaccine candidate: safety and immunogenicity assessment

DV Vasina, DA Kleymenov, VA Manuylov… - Vaccines, 2019 - mdpi.com
Tuberculosis is known to be the biggest global health problem, causing the most deaths by a
single infectious agent. Vaccine-development efforts are extremely important. This paper …

Novel vaccine candidates against Mycobacterium tuberculosis

S Khoshnood, M Heidary, M Haeili, M Drancourt… - International journal of …, 2018 - Elsevier
Tuberculosis (TB) is now among the top ten causes of mortality worldwide being resulted in
1.7 million deaths including 0.4 million among people with HIV in 2016. The Bacille …

[HTML][HTML] Adjuvant strategies for more effective tuberculosis vaccine immunity

E Stewart, JA Triccas, N Petrovsky - Microorganisms, 2019 - mdpi.com
Tuberculosis (TB) caused by Mycobacterium tuberculosis infection is responsible for the
most deaths by a single infectious agent worldwide, with 1.6 million deaths in 2017 alone …

[HTML][HTML] Ensilication improves the thermal stability of the tuberculosis antigen Ag85b and an Sbi-Ag85b vaccine conjugate

AA Wahid, A Doekhie, A Sartbaeva… - Scientific reports, 2019 - nature.com
There is an urgent need for the development of vaccine thermostabilisation methodologies
as the maintenance of a continuous and reliable cold chain remains a major hurdle to the …

[HTML][HTML] Mycobacterium tuberculosis and interactions with the host immune system: opportunities for nanoparticle based immunotherapeutics and vaccines

RB Bekale, SM Du Plessis, NJ Hsu, JR Sharma… - Pharmaceutical …, 2019 - Springer
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a deadly infectious
disease. The thin pipeline of new drugs for TB, the ineffectiveness in adults of the only …

[HTML][HTML] Rescuing ESAT-6 specific CD4 T cells from terminal differentiation is critical for long-term control of murine Mtb infection

HS Clemmensen, NPH Knudsen, R Billeskov… - Frontiers in …, 2020 - frontiersin.org
In most cases, Mycobacterium tuberculosis (Mtb) causes life-long chronic infections, which
poses unique challenges for the immune system. Most of the current tuberculosis (TB) …