The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia.
Because it was initially based on indirect evidence and findings in patients with established …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Prospective epidemiological studies have consistently demonstrated that cannabis use is
associated with an increased subsequent risk of both psychotic symptoms and …

It is evident that once psychosis is present in patients with schizophrenia, the underlying
biological process of the illness has already been ongoing for many years. At the time of …

Importance Cannabidiol (CBD) has antipsychotic effects in humans, but how these are
mediated in the brain remains unclear. Objective To investigate the neurocognitive …

Elevated in vivo markers of presynaptic striatal dopamine activity have been a consistent
finding in schizophrenia, and include a large effect size elevation in dopamine synthesis …

Around 30% of patients with schizophrenia show an inadequate response to antipsychotics—
ie, treatment resistance. Neuroimaging studies can help to uncover the underlying …

Elevated dopamine function and alterations in medial temporal lobe (MTL) structure and
function are two of the most robust findings in schizophrenia, but how interactions between …

The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …

To date, the MRI-based individualized prediction of psychosis has only been demonstrated
in single-site studies. It remains unclear if MRI biomarkers generalize across different …