Envelope biogenesis and homeostasis in gram-negative bacteria are exceptionally intricate
processes that require a multitude of periplasmic chaperones to ensure cellular survival …

Highlights•The BamA β-barrel adopts an open state with its first and last β-strands
unpaired.•BamA β-strand 1 captures the C-terminal β-strand of substrates by hydrogen …

Identification of bacterial protein–protein interactions and predicting the structures of these
complexes could aid in the understanding of pathogenicity mechanisms and developing …

The cell envelope is essential for survival and adaptation of bacteria. Bacterial membrane
proteins include the major porins that mediate the influx of nutrients and several classes of …

To reach their final destinations, outer membrane proteins (OMPs) of gram-negative bacteria
undertake an eventful journey beginning in the cytosol. Multiple molecular machines …

Antimicrobial Resistance (AMR) raises a serious concern as it contributes to the global
mortality by 5 million deaths per year. The overall impact pertaining to significant membrane …

The β-barrel assembly machinery (BAM) complex is essential for localization of surface
proteins on bacterial cells, but the mechanism by which it functions is unclear. We …

PpiD and YfgM are inner membrane proteins that are both composed of an N-terminal
transmembrane segment and a C-terminal periplasmic domain. Escherichia coli YfgM and …

Uptake of thiosulfate ions as an inorganic sulfur source from the environment is important for
bacterial sulfur assimilation. Recently, a selective thiosulfate uptake pathway involving a …

The outer membrane (OM) of Gram-negative bacteria is an essential organelle that protects
cells from external aggressions and mediates the secretion of virulence factors. Efficient …