The evolutionally conserved DNA damage response (DDR) and cell cycle checkpoints
preserve genome integrity. Central to these genome surveillance pathways is a protein …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …

Checkpoint kinase 1 (Chk1) is a master regulator of the DNA damage and replication
checkpoints in vertebrate cells. When activated via phosphorylation by its upstream …

ATR-CHEK1 signalling is critical for genomic stability. ATR-CHEK1 signalling may be
deregulated in breast cancer and have prognostic, predictive and therapeutic significance …

Background Cattleyak are the hybrid offspring between cattle and yak and combine yak
hardiness with cattle productivity. Much attempt has been made to examine the mechanisms …

Replication fork progression is being continuously hampered by exogenously introduced
and naturally occurring DNA lesions and other physical obstacles. Checkpoint kinase 1 …

Background: Checkpoint kinase1 (CHK1), which is a key component of DNA-damage-
activated checkpoint signalling response, may have a role in breast cancer (BC) …

DNA double strand breaks (DSBs) severely disrupt DNA integrity. 53BP1 plays critical roles
in determining DSB repair. Whereas the recruitment of 53BP1 to the DSB site is key for its …

The ATM and Rad3-related (ATR) protein kinase and its downstream effector Chk1 are key
sensors and organizers of the DNA damage response (DDR) to a variety of insults. Previous …

Abstract Checkpoint kinase 1 (Chk1) is a conserved protein kinase central to the cell-cycle
checkpoint during DNA damage response (DDR). Until recently, ATR, a protein kinase …