Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important
role in many physiological and pathological processes in mammalian tissues, with the same …

Time-and space-resolved drug delivery is highly demanded for cancer treatment, which,
however, can barely be achieved with a traditional prodrug strategy. In recent years, the …

Hydrogen sulfide (H2S) is a vital endogenous signal molecule that exerts critical
physiological functions such as biological regulation and cytoprotection. Despite significant …

Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …

Hydrogen sulfide (H 2 S) plays crucial roles in antioxidation, anti-inflammation, and
cytoprotection. Despite substantial progress in the design and synthesis of activatable H 2 S …

Bioorthogonal prodrugs with both fast reaction kinetics and multiple outputs are highly
desirable but are only found sporadically. Herein, we report a novel photoclick‐and‐release …

This paper is dedicated to Prof. Dale L. Boger on the occasion of his receipt of the 2020
Tetrahedron Prize for Creativity. Hydrogen sulfide (H 2 S) is an endogenous signaling …

A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign
byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity …

Mild mitochondrial uncoupling offers therapeutic benefits for various diseases like obesity by
regulating cellular energy metabolism. However, effective chemical intervention tools for …

Herein, we demonstrate that dichloromethanol but not difluoromethanol is a viable surrogate
of carbon monoxide for prodrug design. A proof of concept was established by the …