Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Objective: Fluid administration in combination with the increase in vasopermeability induced
by critical illness often results in significant fluid overload in critically ill patients. Recent …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Acute kidney injury (AKI) is defined by a rapid increase in serum creatinine, decrease in
urine output, or both. AKI occurs in approximately 10–15% of patients admitted to hospital …

Although sepsis and acute kidney injury (AKI) have a bidirectional interplay, the
pathophysiological mechanisms between AKI and sepsis are not clarified and worthy of a …

Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Correction of intravascular hypovolemia is a key component of the prevention and
management of acute kidney injury (AKI), but excessive fluid administration is associated …

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

Objectives: Oxidative stress appears to initiate organ failure in sepsis, justifying treatment
with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety …

Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue
oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia …