Hyperuricemia has long been established as the major etiologic factor in gout. Alongside
with an inflammatory state triggered by urate crystal deposition in the joints, hyperuricemia …

Evidence has emerged that the failing heart increases utilization of ketone bodies. We
sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

cellular apoptosis signaling kinase-1, a redox-sensitive kinase upstream of Jun-nuclear
kinase and p38. Apoptosis signaling kinase-1 overexpression activates nuclear factor κB to …

Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate
promising results, many practical and mechanistic issues regarding this therapy remain …

Well over 2 decades have passed since the endothelium-derived relaxation factor was
reported to be the gaseous molecule nitric oxide (NO). Although soluble guanylyl cyclase …

Heart failure (HF) is a syndrome resulting from the inability of the cardiac pump to meet the
energy requirements of the body. Despite intensive work, the pathogenesis of the cardiac …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Background—Impaired flow-dependent, endothelium-mediated vasodilation (FDD) in
patients with chronic heart failure (CHF) results, at least in part, from accelerated …

Background Experimental evidence suggests that xanthine oxidase inhibitors can reduce
myocardial oxygen consumption for a particular stroke volume. If such an effect also occurs …