Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

Heart failure with preserved ejection fraction (HFpEF) is a widespread syndrome with limited
therapeutic options and poorly understood immune pathophysiology. Using a 2-hit …

Single-cell technology has allowed researchers to probe tissue complexity and dynamics at
unprecedented depth in health and disease. However, the generation of high-dimensionality …

BACKGROUND: Cardiac inflammation in heart failure is characterized by the presence of
damage-associated molecular patterns, myeloid cells, and T cells. Cardiac damage …

The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …

The immune system is intimately involved in the pathophysiology of heart failure. However, it
is currently underused as a therapeutic target in the clinical setting. Moreover, the …

The mammalian heart is characterized by the presence of striated myocytes, which allow
continuous rhythmic contraction from early embryonic development until the last moments of …

Abstract Purpose of Review The intricate interplay between inflammatory and reparative
responses in the context of heart injury is central to the pathogenesis of heart failure. Recent …

The most common form of heart failure is heart failure with preserved ejection fraction
(HFpEF). While heterogeneous in origin, the most common form of HFpEF is the …