After more than a century, aspirin remains one of the most commonly used drugs in western
medicine. Although mainly used for its anti-thrombotic, anti-pyretic, and analgesic properties …

Mid-life stage adults are at higher risk of developing venous thrombosis
(VT)/thromboembolism (VT/E). Aging is characterized by an overproduction of reactive …

Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus
on understanding the possible mechanism of thrombocytopenia in DENV infections we …

Complement activation in the diseases paroxysmal nocturnal hemoglobinuria (PNH) and
atypical hemolytic uremic syndrome (aHUS) results in cytolysis and fatal thrombotic events …

Reactive oxygen species (ROS) are capable of inducing cell death or apoptosis. Recently,
we demonstrated that lipid-ROS can mediate ferroptosis and activation of human platelets …

The fundamental physiology of circulating red blood cells (RBCs) and platelets involving
regulation of oxygen transport and hemostasis, respectively, are well-described in the …

Thrombosis is a common disorder with a relevant burden of morbidity and mortality
worldwide, particularly among elderly patients. Growing evidence demonstrated a direct role …

The lifespan of platelets in circulation is brief, close to 10 days in humans and 5 days in
mice. Bone marrow residing megakaryocytes produce around 100 billion platelets per day …

Thromboembolic events represent the most common complication of hemolytic anemias
characterized by complement-mediated hemolysis such as paroxysmal nocturnal …

Independent of etiology, hemolytic diseases are associated with thrombosis, inflammation
and immune dysregulation, all together contributing to organ damage and poor outcome …