Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

Biogenesis, membrane trafficking, functions, and next generation nanotherapeutics medicine of extracellular vesicles

S Gurunathan, MH Kang, M Qasim… - International Journal of …, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are a heterogeneous group of membrane-limited vesicles and
multi-signal messengers loaded with biomolecules. Exosomes and ectosomes are two …

A comprehensive picture of extracellular vesicles and their contents. Molecular transfer to cancer cells

A Jurj, O Zanoaga, C Braicu, V Lazar, C Tomuleasa… - Cancers, 2020 - mdpi.com
Critical processes such as growth, invasion, and metastasis of cancer cells are sustained via
bidirectional cell-to-cell communication in tissue complex environments. Such …

Extracellular vesicle-mediated communication between the glioblastoma and its microenvironment

ER Matarredona, AM Pastor - Cells, 2019 - mdpi.com
The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple
ways of communication with the tumor microenvironment in order to tune it for their own …

Cancer extracellular vesicles, tumoroid models, and tumor microenvironment

T Eguchi, M Sheta, M Fujii, SK Calderwood - Seminars in Cancer Biology, 2022 - Elsevier
Cancer extracellular vesicles (EVs), or exosomes, promote tumor progression through
enhancing tumor growth, initiating epithelial-to-mesenchymal transition, remodeling the …

Potential role of exosomes in cancer metastasis

W Tian, S Liu, B Li - BioMed research international, 2019 - Wiley Online Library
High cancer mortality is attributed to metastasis to a large extent. However, cancer
metastasis remains devoid of dynamic monitoring and early prevention in terms of current …

Emerging links between endosomal pH and cancer

M Ko, A Quiñones-Hinojosa, R Rao - Cancer and Metastasis Reviews, 2020 - Springer
Extracellular acidification is a well-known driver of tumorigenesis that has been extensively
studied. In contrast, the role of endosomal pH is novel and relatively unexplored. There is …

The peritumoral brain zone in glioblastoma: where we are and where we are going

M Giambra, A Di Cristofori, S Valtorta… - Journal of …, 2023 - Wiley Online Library
Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current
therapies are not curative, and patients' outcomes remain poor with an overall survival of …

Drug sequestration in lysosomes as one of the mechanisms of chemoresistance of cancer cells and the possibilities of its inhibition

J Hraběta, M Belhajová, H Šubrtová… - International journal of …, 2020 - mdpi.com
Resistance to chemotherapeutics and targeted drugs is one of the main problems in
successful cancer therapy. Various mechanisms have been identified to contribute to drug …

[HTML][HTML] Large extracellular vesicles: Size matters in tumor progression

C Ciardiello, R Migliorino, A Leone… - Cytokine & Growth Factor …, 2020 - Elsevier
Abstract Extracellular Vesicles (EVs) represent a heterogeneous population of particles
naturally released from all cells, delimited by a lipid bilayer and able to horizontally transfer …