Aging is a major cause of many degenerative diseases. The most intuitive consequence of
aging is mainly manifested on the skin, resulting in cumulative changes in skin structure …

For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

During the last few decades, improvements in the planning and application of radiotherapy
in combination with surgery and chemotherapy resulted in increased survival rates of tumor …

The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However,
this is a disguise that conceals a highly active metabolic cell state with diverse functionality …

Macroautophagy/autophagy has profound implications for aging. However, the true features
of autophagy in the progression of aging remain to be clarified. In the present study, we …

Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response
to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of …

Objectives The use of doxorubicin, a drug utilised for many years to treat a wide variety of
cancers, has long been limited due to the significant toxicity that can occur not only during …

It is generally thought that autophagy has two primary and opposing functions in tumor cells
in response to stress induced by chemotherapy or radiation. One is the cytoprotective …

Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making
them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers …

Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into
myofibroblasts. Cellular senescence, another means of responding to long-term cellular …