Interplay between miRNAs and host genes and their role in cancer

B Liu, Y Shyr, J Cai, Q Liu - Briefings in functional genomics, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-
transcriptionally regulate gene expression. They play essential roles in nearly all biological …

Control mechanisms of the tumor suppressor PDCD4: expression and functions

S Matsuhashi, M Manirujjaman, H Hamajima… - International journal of …, 2019 - mdpi.com
PDCD4 is a novel tumor suppressor to show multi-functions inhibiting cell growth, tumor
invasion, metastasis, and inducing apoptosis. PDCD4 protein binds to the translation …

Development of microRNAs as potential therapeutics against cancer

N Abd-Aziz, NI Kamaruzman, CL Poh - Journal of oncology, 2020 - Wiley Online Library
MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional
level in the cellular regulation process. miRNA expression exerts vital effects on cell growth …

Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways

A Amirfallah, H Knutsdottir, A Arason, B Hilmarsdottir… - PloS one, 2021 - journals.plos.org
Breast cancer is the cancer most often diagnosed in women. MicroRNAs (MIRs) are short
RNA molecules that bind mRNA resulting in their downregulation. MIR21 has been shown to …

MiRNA-183-5p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting the PDCD4

Y Cheng, G Xiang, Y Meng, R Dong - Reproductive biology, 2016 - Elsevier
MicroRNAs are often aberrantly expressed in breast cancer and postulated to play a causal
role in the onset and maintenance of breast cancer by binding to its target mRNA. Here, we …

Development of novel therapeutic agents by inhibition of oncogenic microRNAs

DD Nguyen, S Chang - International journal of molecular sciences, 2017 - mdpi.com
MicroRNAs (miRs, miRNAs) are regulatory small noncoding RNAs, with their roles already
confirmed to be important for post-transcriptional regulation of gene expression affecting cell …

microRNA-499a promotes the progression and chemoresistance of cervical cancer cells by targeting SOX6

Y Chen, Y Song, Y Mi, H Jin, J Cao, H Li, L Han… - Apoptosis, 2020 - Springer
Emerging evidence has indicated that microRNAs are involved in multiple processes of
cancer development. Previous studies have demonstrated that microRNA-499a (miR-499a) …

[HTML][HTML] Extracellular vesicles in oral squamous carcinoma carry oncogenic miRNA profile and reprogram monocytes via NF-κB pathway

F Momen-Heravi, S Bala - Oncotarget, 2018 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are carriers of different biomacromolecules that participate in
cellular signaling and disease pathogenesis. Although it has been shown that EVs can play …

Circulating MicroRNAs: biogenesis and clinical significance in acute myocardial infarction

L Zhang, H Ding, Y Zhang, Y Wang, W Zhu… - Frontiers in …, 2020 - frontiersin.org
Acute myocardial infarction (AMI) causes many deaths around the world. Early diagnosis
can prevent the development of AMI and provide theoretical support for the subsequent …

[HTML][HTML] MiR-21 as prognostic biomarker in head and neck squamous cell carcinoma patients undergoing an organ preservation protocol

LMRB Arantes, AC Laus, ME Melendez… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Despite progress in the treatment of head and neck squamous cell carcinoma (HNSCC) in
recent decades, including new surgical techniques, radiotherapy advances and …