The RAS gene family is one of the most frequently mutated oncogenes in human cancers. In
KRAS, mutations of G12D and G12C are common. Here, 52 iridoids were selected and …

In recent years, preclinical research on diabetic kidney disease (DKD) has surged to the
forefront of scientific and clinical attention. DKD has become a pervasive complication of …

Natural products have been used for treatment of various diseases for thousands of years
and served as sources of drug lead compounds for the improvement of livelihood. This …

The cycloaddition and annulation reactions of Achmatowicz rearrangement products (ARPs)
are critically important to the construction of molecular complexity and the total synthesis of …

Glioblastoma presents one of the most formidable challenges in cancer treatment, remaining
persistently incurable. There is a pressing need to explore less toxic alternatives, particularly …

Cervical cancer is a malignant neoplastic disease, mainly associated to HPV infection, with
high mortality rates. Among natural products, iridoids have shown different biological …

KRAS mutations linked with cancer. Flavonoids were docked against KRAS G12C and
G12D receptors. Abyssinone III, alpha naphthoflavone, beta naphthoflavone, abyssinone I …

Iridoids commonly found in plants as secondary metabolites have been reported to possess
significant biological activities such as anticancer, antioxidant, hypoglycemic, antimicrobial …

The influence of UV radiation on skin discoloration, skin aging and the development of skin
cancer is widely known. As a part of this study, the effect of extracts from three varieties of …

The iridoid class of phytochemicals includes important phytochemicals found in many
traditional medicinal plants. Plumieride and plumericin have been isolated from Allamanda …