Vitamin B 6 is one of the most central molecules in cells of living organisms. It is a critical co-
factor for a diverse range of biochemical reactions that regulate basic cellular metabolism …

Aldehyde dehydrogenases engage in many cellular functions, however their dysfunction
resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the …

Reactive oxygen species (ROS) are continuously generated within living systems and the
inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative …

Vitamin B6 is present in our diet in many forms, however, only pyridoxal 5′‐phosphate
(PLP) can function as a cofactor for enzymes. The intestine absorbs nonphosphorylated B6 …

Super-refractory status epilepticus is defined as status epilepticus that continues or recurs
24 h or more after the onset of anaesthetic therapy, including those cases where status …

Although amino acids are critical for all forms of life, only proteogenic amino acids that
humans and animals cannot synthesize de novo and therefore must acquire in their diets …

Background: Aldehydes are highly reactive molecules. While several non-P450 enzyme
systems participate in their metabolism, one of the most important is the aldehyde …

Neonatal seizures constitute the most frequent and distinctive neurological symptom in the
neonatal period. Seizures in the neonatal period differ considerably from those observed …

Defects in PEX genes impair peroxisome assembly and multiple metabolic pathways
confined to this organelle, thus providing the biochemical and molecular bases of the …

It is increasingly evident that metabolites suffer various kinds of damage, that such damage
happens in all organisms and that cells have dedicated systems for damage repair and …