Effect of age and sex on gene expression-based radiation biodosimetry using mouse peripheral blood

CG Broustas, I Shuryak, AJ Duval… - Cytogenetic and genome …, 2023 - karger.com
Blood-based gene expression profiles that can reconstruct radiation exposure are being
developed as a practical approach to radiation biodosimetry. However, age and sex could …

Host microbiome depletion attenuates biofluid metabolite responses following radiation exposure

EL Pannkuk, I Shuryak, A Kot, L Yun-Tien Lin, HH Li… - Plos one, 2024 - journals.plos.org
Development of novel biodosimetry assays and medical countermeasures is needed to
obtain a level of radiation preparedness in the event of malicious or accidental mass …

Cross-platform validation of a mouse blood gene signature for quantitative reconstruction of radiation dose

SA Ghandhi, I Shuryak, B Ponnaiya, X Wu, G Garty… - Scientific Reports, 2022 - nature.com
In the search for biological markers after a large-scale exposure of the human population to
radiation, gene expression is a sensitive endpoint easily translatable to in-field high …

[HTML][HTML] Effects of High-Linear-Energy-Transfer Heavy Ion Radiation on Intestinal Stem Cells: Implications for Gut Health and Tumorigenesis

S Kumar, S Suman, J Angdisen, BH Moon… - Cancers, 2024 - mdpi.com
Simple Summary Heavy ion radiation, found in outer space and used in some cancer
treatments, can damage vital cells in the intestines. Studies using mice show that this type of …

Impact of GADD45A on radiation biodosimetry using mouse peripheral blood

CG Broustas, S Mukherjee, I Shuryak… - Radiation …, 2023 - meridian.allenpress.com
High-dose-radiation exposure in a short period of time leads to radiation syndromes
characterized by severe acute and delayed organ-specific injury accompanied by elevated …

Assessing Onsager's reciprocity difference in signal transduction cascade model: a new metric for evaluating cellular response dynamics

M Taga, G Kobayashi, S Yano, K Koyama… - The European Physical …, 2024 - Springer
The cell signaling system translates extracellular changes into biochemical reactions within
the cell, ultimately affecting gene expression. This system is crucial for responding to …