Limbal stem cell deficiency: current treatment options and emerging therapies

M Haagdorens, SI Van Acker… - Stem cells …, 2016 - Wiley Online Library
Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition
leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular …

Recent advances in stem cell therapy for limbal stem cell deficiency: a narrative review

AE Ghareeb, M Lako, FC Figueiredo - Ophthalmology and therapy, 2020 - Springer
Destruction of the limbus and depletion of limbal stem cells (LSCs), the adult progenitors of
the corneal epithelium, leads to limbal stem cell deficiency (LSCD). LSCD is a rare …

Global consensus on definition, classification, diagnosis, and staging of limbal stem cell deficiency

SX Deng, V Borderie, CC Chan, R Dana… - Cornea, 2019 - journals.lww.com
Purpose: Despite extensive knowledge gained over the last 3 decades regarding limbal
stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of …

Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review

JV Cabral, CJ Jackson, TP Utheim, K Jirsova - Stem Cell Research & …, 2020 - Springer
Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or
bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first …

[HTML][HTML] Cell identity changes in ocular surface Epithelia

N Di Girolamo, M Park - Progress in Retinal and Eye Research, 2023 - Elsevier
Corneal and conjunctival epithelia arise from a common ancestral ectoderm cell, then
diverge into distinct lineages. The former develops into a multilayered stratified squamous …

From discovery to approval of an advanced therapy medicinal product-containing stem cells, in the EU

G Pellegrini, A Lambiase, C Macaluso… - Regenerative …, 2016 - Taylor & Francis
In 1997, the human corneal epithelium was reconstructed in vitro and transplanted on
patients. Later, it became a routine treatment, before regulations considered advanced …

Corneal epithelial thickness measured using anterior segment optical coherence tomography as a diagnostic parameter for limbal stem cell deficiency

Q Liang, Q Le, DW Cordova, CH Tseng… - American Journal of …, 2020 - Elsevier
Objective Using anterior segment optical coherence tomography (AS-OCT), we investigated
the epithelial thickness (ET) of the central cornea and limbal regions in patients with limbal …

Limbal epithelial cell therapy: past, present, and future

TP Utheim - Corneal Regenerative Medicine: Methods and …, 2013 - Springer
The cornea, the clear window at the front of the eye, transmits light to the retina to enable
vision. The corneal surface is renewed by stem cells located at the peripheral limbal region …

[HTML][HTML] Efficacy and outcome of simple limbal epithelial transplantation for limbal stem cell deficiency verified by epithelial phenotypes integrated with clinical …

P Prabhasawat, C Chirapapaisan, P Ngowyutagon… - The Ocular Surface, 2021 - Elsevier
Purpose To evaluate the efficacy and outcome of simple limbal epithelial transplantation
(SLET) for limbal stem cell deficiency (LSCD) using epithelial phenotype detection …

Immunocytochemical diagnosis of limbal stem cell deficiency: comparative analysis of current corneal and conjunctival biomarkers

M Poli, C Burillon, C Auxenfans, MR Rovere, O Damour - Cornea, 2015 - journals.lww.com
Purpose: To evaluate and compare corneal and conjunctival biomarkers for
immunocytochemical diagnosis of limbal stem cell deficiency (LSCD). Methods: In …