Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Sepsis is a life-threatening organ dysfunction responsible for nearly 270,000 deaths
annually in the United States alone. Nicotinamide adenine dinucleotide (NAD+), an …

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Background & Aims Pancreatitis starts with primarily sterile local inflammation that induces
systemic inflammatory response syndrome, followed by compensatory anti-inflammatory …

Background Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we
previously reported that peripheral infusion of human umbilical cord mesenchymal stem …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following
abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and …

Background Impaired or hyperactive pancreas regeneration after injury would cause
exocrine insufficiency or recurrent/chronic pancreatitis and potentially carcinogenesis …