Prostaglandins, leukotrienes, platelet-activating factor, lysophosphatidic acid, sphingosine 1-
phosphate, and endocannabinoids, collectively referred to as lipid mediators, play pivotal …

Cell membranes contain several classes of glycerophospholipids, which have numerous
structural and functional roles in the cells. Polyunsaturated fatty acids, including arachidonic …

All organisms consist of cells that are enclosed by a cell membrane containing bipolar lipids
and proteins. Glycerophospholipids are important not only as structural and functional …

Phospholipids are present in all living organisms. They are a major component of all
biological membranes, along with glycolipids and cholesterol. Enzymes aimed at modifying …

Platelet-activating factor (PAF) is a potent proinflammatory lipid mediator eliciting a variety of
cellular functions. Lipid mediators, including PAF are produced from membrane …

Abstract Phospholipases A2 (PLA2s) belong to a superfamily of enzymes responsible for
hydrolyzing the sn-2 fatty acids of membrane phospholipids. These enzymes are known to …

Small lipids such as eicosanoids exert diverse and complex functions. In addition to their
role in regulating normal kidney function, these lipids also play important roles in the …

The lipid monolayer model membrane is useful for studying the parameters responsible for
protein and peptide membrane binding. Different approaches have been used to determine …

Background: Manoalide (MA), a proven natural inhibitor of PLA2 has anticancer effects, but
its potential application and mechanism as an anticancer drug to promote EGFR-TKI …

The arachidonic acid (AA) cascade produces eicosanoids, such as prostaglandins (PGs),
that regulate physiological and pathological functions. Although various nonsteroidal anti …