Approaching the catalytic mechanism of protein lysine methyltransferases by biochemical and simulation techniques
Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …
[HTML][HTML] SMYD3: a regulator of epigenetic and signaling pathways in cancer
BJ Bernard, N Nigam, K Burkitt, V Saloura - Clinical Epigenetics, 2021 - Springer
Chromatin modifiers and their implications in oncogenesis have been an exciting area of
cancer research. These are enzymes that modify chromatin via post-translational …
cancer research. These are enzymes that modify chromatin via post-translational …
[HTML][HTML] The catalytic mechanism of the RNA methyltransferase METTL3
The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme
that deposits N 6-methyladenosine (m 6 A) modifications on messenger RNA (mRNA) in …
that deposits N 6-methyladenosine (m 6 A) modifications on messenger RNA (mRNA) in …
[HTML][HTML] Mechanism of the conformational change of the protein methyltransferase SMYD3: a molecular dynamics simulation study
J Sun, Z Li, N Yang - International Journal of Molecular Sciences, 2021 - mdpi.com
SMYD3 is a SET-domain-containing methyltransferase that catalyzes the transfer of methyl
groups onto lysine residues of substrate proteins. Methylation of MAP3K2 by SMYD3 has …
groups onto lysine residues of substrate proteins. Methylation of MAP3K2 by SMYD3 has …
[HTML][HTML] SMYD3 promotes colon adenocarcinoma (COAD) progression by mediating cell proliferation and apoptosis
FR Yue, ZB Wei, RZ Yan, QH Guo… - Experimental and …, 2020 - spandidos-publications.com
Colon adenocarcinoma (COAD) is a type of common malignant tumor originating in the
digestive tract. Recently, targeted therapy has had significant effects on the treatment of …
digestive tract. Recently, targeted therapy has had significant effects on the treatment of …
Role of MEKK2 Phosphorylation at Threonine 263 on SMYD3-Mediated Methylation of Lysine 260
RN Corridore - 2024 - yorkspace.library.yorku.ca
MEKK2 is a protein serine/threonine-kinase involved in the activation of many MAP-kinase
signalling pathways. In a previous study, SMYD3-mediated methylation at K260 of MEKK2 …
signalling pathways. In a previous study, SMYD3-mediated methylation at K260 of MEKK2 …