Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but
also may play roles in developing cardiovascular diseases such as hypertension, atrial …

Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase
and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from …

Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …

Serum uric acid (SUA) levels discriminating across the different strata of cardiovascular risk
is still unknown. By utilizing a large population-based database, we assessed the threshold …

2002 年日本痛风核酸代谢协会在全球首次提出: 对无症状高尿酸血症(HUA)
应根据心血管危险因素或并存的心血管疾病给予分层治疗. 我国存在着大量合并多种心血管危险 …

Prehypertension frequently progresses to hypertension, a condition associated with high
morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors …

Uric acid is the end product of purine metabolism catalyzed by xanthine oxidase in humans.
In the process of purine metabolism, reactive oxygen species, including superoxide, are …

Hyperuricemia is associated with hypertension, vascular disease, renal disease, and
cardiovascular events. In this report, we review the epidemiologic evidence and potential …

Serum uric acid (UA) is taken up by endothelial cells and reduces the level of nitric oxide
(NO) by inhibiting its production and accelerating its degradation. Cytosolic and plasma …

Previous studies have reported that uric acid stimulates vascular smooth muscle cell
(VSMC) proliferation in vitro. We hypothesized that uric acid may also have direct …